 The eleventh annual international conference on Research in Computational Molecular Biology (RECOMB 2007) recently concluded in the San Francisco bay area. With an annual acceptance rate of only 18%, RECOMB is the premier conference on computational methods for biology. Dr. T. M. Murali along with CS Ph.D student Corban Rivera presented their current research at the conference. Corban Rivera spoke on the topic of "Network Legos". GBCB Ph.D student Matthew Dyer along with T. M. Murali and Bruno Sobral, Executive and Scientific Director,VBI, presented a poster at RECOMB.
We provide a brief description of the topics below.
T. M. Murali and Corban Rivera. "Network Legos: Building Blocks of Cellular Wiring Diagrams"
Network Legos represent the building blocks cellular stress response. The building blocks are composed of coherently interacting genes and gene products in the cellular wiring diagram. We automatically compute these building blocks by systematically combining response networks computed for different cellular stress conditions using set-theoretic formulas.
Matthew Dyer, T. M. Murali, and Burno Sobral. "Computational prediction of host-pathogen protein interactions"
Host-pathogen protein-protein interactions (PPIs) play a vital role in initiating infection. Identifying which PPIs enable a pathogen to invade its host provides us with potential targets for therapeutics. We compute statistical measures from known instances of interacting proteins and use these to predict new interactions in host-pathogen interactions.
Along with collaborators at VBI and the Department of Biochemistry, the Computer Science Department at Virginia Tech is making exciting discoveries in the field of computational biology.
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