Computational and Evolutionary Genomics

URL: http://bioinformatics.cs.vt.edu/~zhanglab

Contact: Liqing Zhang

We analyze genomes to infer interesting evolutionary events, with a focus on the divergence of duplicated genes in both primary sequences and function. We develop methods to analyze the human SNPs (single nucleotide polymorphisms) to understand the associations between different genetic diseases. We also develop open source software and online databases for analyzing high throughput data. We are currently developing a program for detecting gene conversion (non-reciprocal transfer of genetic information from one sequence to another) using machine learning approach.

2015
Chen, W., and L. Zhang, "The pattern of DNA cleavage intensity around indels", Scientific reports, vol. 5: Nature Publishing Group, 2015.
Tran, H., X. Wu, and L. Zhang, "A Bayesian Method for Assigning Ambiguous Bisulfite Short Reads", The 7th International Conference on Bioinformatics and Computational Biology (BICoB-2015), Hawaii, 2015.
Feng, W., K. Krommydas, and L. Zhang, "CentroidBLAST: A Cluster- Based Approach to Sequence Search", The 7th International Conference on Bioinformatics and Com- putational Biology (BICoB-2015), Hawaii, 2015.
2014
2012
Huang, Y., M. Liu, and L. Zhang, "Gene Selection for Cancer Classification by Multiple PCA with Sparsity", Fourth International Conference on Bioinformatics and Computational Biology (BICoB-2012), Las Vegas, 2012.
2011
Lawson, M. J., L. S. Heath, H. Zhao, and L. Zhang, "Optimizing a Cost Matrix to Solve Rare-Class Biological Problems", 2011 International Conference on Bioinformatics and Computational Biology (BIOCOMP'11), Las Vegas, Nevada, 2011.
Zhang, L., L. T. Watson, and L. S. Heath, "A Network of Hidden Markov Models and Its Analysis", 2011 International Conference on Bioinformatics and Computational Biology (BIOCOMP'11), Las Vegas, Nevada, 2011.
2010
2009
2008
2007
2006
2005
2004
2003
2002
2001